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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 269183Generated: October 29, 2026

2-Chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiazole-5-sulfonamide → HCID 86608058, compound

https://huagongshe.com/reaction/269183

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiazole-5-sulfonamideHCID 61052651—
Reactant3-Ethynyl-7-trifluoromethyl-5-(3-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidineHCID 86608055—
ProductHCID 86608058HCID 86608058—

Reaction Steps

The title compound was prepared from 3-ethynyl-7-trifluoromethyl-5-(3-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.10) (178 mg, 0.5 mmol) and 2-chloro-thiazole-5-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide (example B.14) (135 mg, 0.5 mmol) according to general procedure II. Obtained as a yellow solid (163 mg, 55%). MS (ISN) 588.2 [(M+H)+]; mp 200° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07446113B2
Source datasetuspto-grants-2008_11
ORD IDord-a6d0c09db3164e8798f3f352eed988fa
Source noteuspto-grants-2008_11