HRID269214

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3696002

4-(3-Bromobenzene-1-sulfonyl)morpholine

C10H12BrNO3S

结构：C#Cc1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12

HCID86608034

未命名化合物

PRODUCTS

生成物

结构：O=S(=O)(c1cccc(C#Cc2cnn3c(C(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)c1)N1CCOCC1

HCID11852826

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 7-difluoromethyl-3-ethynyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.2) (340 mg, 1.0 mmol) and 4-(3-bromo-benzenesulfonyl)-morpholine (example B.31) (275 mg, 1.0 mmol) according to general procedure II. Obtained as a yellow solid (390 mg, 68%). MS (ISP) 563.4 [(M+H)+]; mp 175-176° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3f94d55539bf435babb2ed8d864a11bc
来源数据集: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07446113B2
来源说明: uspto-grants-2008_11

反应 SMILES

[F:1][CH:2]([F:24])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]#[CH:13])=[C:7]2[N:6]=[C:5]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH:4]=1.Br[C:26]1[CH:27]=[C:28]([S:32]([N:35]2[CH2:40][CH2:39][O:38][CH2:37][CH2:36]2)(=[O:34])=[O:33])[CH:29]=[CH:30][CH:31]=1>>[F:24][CH:2]([F:1])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]#[C:13][C:30]3[CH:31]=[CH:26][CH:27]=[C:28]([S:32]([N:35]4[CH2:40][CH2:39][O:38][CH2:37][CH2:36]4)(=[O:34])=[O:33])[CH:29]=3)=[C:7]2[N:6]=[C:5]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH:4]=1