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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 269257Generated: October 30, 2026

2-Chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiazole-5-sulfonamide → HCID 16738478, compound

https://huagongshe.com/reaction/269257

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-N-(1-hydroxy-2-methylpropan-2-yl)thiazole-5-sulfonamideHCID 61052651—
Reactant3-Ethynyl-8-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridineHCID 86608011—
ProductHCID 16738478HCID 16738478—

Reaction Steps

The title compound was prepared from 3-ethynyl-8-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine (example C.18) (354 mg, 1 mmol) and 2-chloro-thiazole-5-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide (example B.19) (244 mg, 0.9 mmol) according to general procedure II. Obtained as a yellow solid (77 mg, 13%). MS (ISP) 589.3 [(M+H)+]; mp 202-203° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07446113B2
Source datasetuspto-grants-2008_11
ORD IDord-b36d333f2caf40799f6e36b596047915
Source noteuspto-grants-2008_11