HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Ethynylpyridin-2-amine → 5-[6-(4-Chloro-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-ylethynyl]-pyridin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Ethynylpyridin-2-amine | HCID 21954827 | — |
| Reactant | 6-(4-Chloro-phenyl)-3-iodo-8-methyl-imidazo[1,2-a]pyridine | HCID 67000648 | — |
| Product | 5-[6-(4-Chloro-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-ylethynyl]-pyridin-2-ylamine | HCID 16738442 | — |
Reaction Steps
The title compound was prepared from 6-(4-chloro-phenyl)-3-iodo-8-methyl-imidazo[1,2-a]pyridine (example C.21 step 2) (737 mg, 2 mmol) and 5-ethynyl-pyridin-2-ylamine (example D.1) (307 mg, 2.6 mmol) according to general procedure II. Obtained as an off-white solid (240 mg, 33%). MS (ISP) 359.0 [(M+H)+], 361.0 [(M+2+H)+]; mp 231-234° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446113B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-bc697b8db46a4a4891fb5c95e8cd5d65 |
| Source note | uspto-grants-2008_11 |