5-Bromo-2-thiophenesulfonamide → HCID 16738477, compound

HRID 269283Notes

Reaction equation

HRID 269283 reaction equation
[CH:1]1([C:4]2[C:5]3[N:6]([C:20]([C:23]#[CH:24])=[CH:21][N:22]=3)[CH:7]=[C:8]([C:10]3[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=3)[CH:9]=2)[CH2:3][CH2:2]1.Br[C:26]1[S:30][C:29]([S:31]([NH2:34])(=[O:33])=[O:32])=[CH:28][CH:27]=1>>[CH:1]1([C:4]2[C:5]3[N:6]([C:20]([C:23]#[C:24][C:26]4[S:30][C:29]([S:31]([NH2:34])(=[O:33])=[O:32])=[CH:28][CH:27]=4)=[CH:21][N:22]=3)[CH:7]=[C:8]([C:10]3[CH:11]=[CH:12][C:13]([C:16]([F:18])([F:17])[F:19])=[CH:14][CH:15]=3)[CH:9]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 12413045-Bromo-2-thiophenesulfonamideHCID 86608103HCID 86608103, compound

Product 1

HCID 16738477HCID 16738477, compound

Procedure

The title compound was prepared from 8-cyclopropyl-3-ethynyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine (example C.25) (450 mg, 1.3 mmol) and commercially available 5-bromothiophene-2-sulfonamide (334 mg, 1.3 mmol) according to general procedure II. Obtained as a light yellow solid (200 mg, 29%). MS (ISP) 488.2 [(M+H)+]; mp 261° C.

Sources & evidence

ORD record
ord-9f052e61f01f4967b8b5d85f0d60f835
Source dataset
uspto-grants-2008_11
Patent number
US07446113B2

Reaction notes

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