5-bromo-N-(1-hydroxy-2-methylpropan-2-yl)pyridine-3-sulfonamide → 5-[6-(4-Chloro-phenyl)-8-methyl-imidazo [1,2-a]pyridin-3-ylethynyl]-pyridine-3-sulfonic acid(2-hydroxy-1,1-dimethyl-ethyl)-amide

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Reaction Steps

The title compound was prepared from 6-(4-chloro-phenyl)-3-ethynyl-8-methyl-imidazo[1,2-a]pyridine (example C.21) (270 mg, 1 mmol) and 5-bromo-pyridine-3-sulfonic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide (example B.2) (282 mg, 0.9 mmol) according to general procedure II. Obtained as a light yellow solid (180 mg, 35%). MS (ISP) 495.0 [(M+H)+], 497 [(M+2+H)+]; mp 215-217° C.

Provenance & Evidence