HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 3-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | 3-(2',4'-Difluoro-4-biphenylyl)butyric acid | HCID 21322540 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid | HCID 21322583 | — |
Reaction Steps
3.55 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-bromobutyric acid, obtained by brominating 3-(2',4'-difluoro-4-biphenylyl)butyric acid, are dissolved in a mixture of 15 ml. of acetone and 15 ml. of water. One drop of sulfuric acid is added and the mixture is warmed to 45° for 4 hours and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid, m.p. 121°-123°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04151302 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-7bf96ead76564b4eb602b3d5ce0c6aa1 |
| Source note | uspto-grants-1979_04 |