HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromopyridine-3-sulfonamide → 5-[6-(4-Chloro-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-ylethynyl]-pyridine-3-sulfonic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromopyridine-3-sulfonamide | HCID 12684258 | — |
| Reactant | 6-(4-Chloro-phenyl)-3-ethynyl-8-methyl-imidazo[1,2-a]pyridine | HCID 86608094 | — |
| Product | 5-[6-(4-Chloro-phenyl)-8-methyl-imidazo[1,2-a]pyridin-3-ylethynyl]-pyridine-3-sulfonic acid amide | HCID 16735269 | — |
Reaction Steps
The title compound was prepared from 6-(4-chloro-phenyl)-3-ethynyl-8-methyl-imidazo[1,2-a]pyridine (example C.21) (270 mg, 1 mmol) and 5-bromo-pyridine-3-sulfonic acid amide (example B.1) (216 mg, 0.9 mmol) according to general procedure II. Obtained as a yellow solid (20 mg, 5%). MS (ISP) 495.0 [(M+H)+], 497 [(M+2+H)+]; mp 282° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446113B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-9386ed5ac81241dd8eb82128e60241d7 |
| Source note | uspto-grants-2008_11 |