1-[(5-Bromo-2-thienyl)sulfonyl]-4-methylpiperazine → HCID 86608107, compound

HRID 269306Notes

Reaction equation

HRID 269306 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][N:6]2[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=3)=[N:8][C:7]=12)#[CH:2].Br[C:27]1[S:31][C:30]([S:32]([N:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)(=[O:34])=[O:33])=[CH:29][CH:28]=1>>[CH3:41][N:38]1[CH2:37][CH2:36][N:35]([S:32]([C:30]2[S:31][C:27]([C:2]#[C:1][C:3]3[CH:4]=[N:5][N:6]4[C:11]([C:12]([F:14])([F:13])[F:15])=[CH:10][C:9]([C:16]5[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=5)=[N:8][C:7]=34)=[CH:28][CH:29]=2)(=[O:34])=[O:33])[CH2:40][CH2:39]1

Participants

3

Reactant 2

HCID 6621571-[(5-Bromo-2-thienyl)sulfonyl]-4-methylpiperazineHCID 866080553-Ethynyl-7-trifluoromethyl-5-(3-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 86608107HCID 86608107, compound

Procedure

The title compound was prepared from 3-ethynyl-7-trifluoromethyl-5-(3-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.10) (178 mg, 0.5 mmol) and 1-(5-bromo-thiophene-2-sulfonyl)-4-methyl-piperazine (example B.50) (163 mg, 0.5 mmol) according to general procedure II. Obtained as an orange solid (210 mg, 70%). MS (EI) 599.1 [(M)+]; mp 191° C.

Sources & evidence

ORD record
ord-197c9134e77249ff945d0f9c2f605c6f
Source dataset
uspto-grants-2008_11
Patent number
US07446113B2

Reaction notes

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