1-[(5-Bromo-2-thienyl)sulfonyl]-4-methylpiperazine → 5-(4-Chloro-3-methyl-phenyl)-3-[5-(4-methyl-piperazine-1-sulfonyl)-thiophen-2-ylethynyl]-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine

Participants

Role	Name	HCID	Charge
Reactant	1-[(5-Bromo-2-thienyl)sulfonyl]-4-methylpiperazine	HCID 662157	—
Reactant	5-(4-Chloro-3-methyl-phenyl)-3-ethynyl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine	HCID 86608053	—
Product	5-(4-Chloro-3-methyl-phenyl)-3-[5-(4-methyl-piperazine-1-sulfonyl)-thiophen-2-ylethynyl]-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine	HCID 67001099	—

Reaction Steps

The title compound was prepared from 5-(4-chloro-3-methyl-phenyl)-3-ethynyl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine (example C.11) (168 mg, 0.5 mmol) and 1-(5-bromo-thiophene-2-sulfonyl)-4-methyl-piperazine (example B.50) (163 mg, 0.5 mmol) according to general procedure II. Obtained as a yellow solid (220 mg, 76%). MS (ISP) 580.0 [(M+H)+]; mp 229° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07446113B2
Source dataset	uspto-grants-2008_11
ORD ID	ord-cd2f78da624843e78520e67bbbe197c8
Source note	uspto-grants-2008_11