HRID269338

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID933073

未命名化合物

结构：C#Cc1cnn2c(C(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12

HCID86608034

未命名化合物

PRODUCTS

生成物

结构：O=S(=O)(Nc1cccnc1)c1ccc(C#Cc2cnn3c(C(F)F)cc(-c4ccc(C(F)(F)F)cc4)nc23)s1

HCID67001281

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 7-difluoromethyl-3-ethynyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.2) (169 mg, 0.5 mmol) and commercially available 5-bromo-thiophene-2-sulfonic acid pyridin-3-ylamide [CAS-No. 439934-18-6] (160 mg, 0.5 mmol) according to general procedure II. Obtained as a yellow solid (220 mg, 76%). MS (ISN) 574.1 [(M−H)−]; mp 226° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a87f0674d08b49929f524b7a561c11a3
来源数据集: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07446113B2
来源说明: uspto-grants-2008_11

反应 SMILES

[F:1][CH:2]([F:24])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]#[CH:13])=[C:7]2[N:6]=[C:5]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[CH:4]=1.[N:25]1[CH:30]=[CH:29][CH:28]=[C:27]([NH:31][S:32]([C:35]2[S:36][C:37](Br)=[CH:38][CH:39]=2)(=[O:34])=[O:33])[CH:26]=1>>[N:25]1[CH:30]=[CH:29][CH:28]=[C:27]([NH:31][S:32]([C:35]2[S:36][C:37]([C:13]#[C:12][C:11]3[CH:10]=[N:9][N:8]4[C:3]([CH:2]([F:1])[F:24])=[CH:4][C:5]([C:14]5[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=5)=[N:6][C:7]=34)=[CH:38][CH:39]=2)(=[O:33])=[O:34])[CH:26]=1