2-Amino-5-bromopyridine → HCID 67001219, compound

HRID 269348Notes

Reaction equation

HRID 269348 reaction equation
[CH:1]1([C:4]2[N:9]3[N:10]=[CH:11][C:12]([C:13]#[CH:14])=[C:8]3[N:7]=[C:6]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[CH:5]=2)[CH2:3][CH2:2]1.[NH2:25][C:26]1[CH:31]=[CH:30][C:29](Br)=[CH:28][N:27]=1>>[CH:1]1([C:4]2[N:9]3[N:10]=[CH:11][C:12]([C:13]#[C:14][C:29]4[CH:30]=[CH:31][C:26]([NH2:25])=[N:27][CH:28]=4)=[C:8]3[N:7]=[C:6]([C:15]3[CH:16]=[CH:17][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:19][CH:20]=3)[CH:5]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 866080497-Cyclopropyl-3-ethynyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 67001219HCID 67001219, compound

Procedure

The title compound was prepared from 7-cyclopropyl-3-ethynyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.7) (82 mg, 0.25 mmol) and 2-amino-5-bromopyridine (43 mg, 0.25 mmol) according to general procedure II. Obtained as an orange solid (9 mg, 9%). MS (ISP) 420.2 [(M+H)+]; mp 228-231° C.

Sources & evidence

ORD record
ord-8bfe1951fdb34247aac8b8b902556cbc
Source dataset
uspto-grants-2008_11
Patent number
US07446113B2

Reaction notes

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