HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Ethynylpyridin-2-amine → 5-[5-(4-Chloro-phenyl)-7-propyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyridin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Ethynylpyridin-2-amine | HCID 21954827 | — |
| Reactant | 5-(4-Chloro-phenyl)-3-iodo-7-propyl-pyrazolo[1,5-a]pyrimidine | HCID 67000949 | — |
| Product | 5-[5-(4-Chloro-phenyl)-7-propyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-pyridin-2-ylamine | HCID 67000891 | — |
Reaction Steps
The title compound was prepared from 5-(4-chloro-phenyl)-3-iodo-7-propyl-pyrazolo[1,5-a]pyrimidine (99 mg, 0.25 mmol) and 5-ethynyl-pyridin-2-ylamine (example D.1) (30 mg, 0.25 mmol) according to general procedure II. Obtained as a yellow solid (48 mg, 50%). MS (ISP) 388.4 [(M+H)+]; mp 215-217° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446113B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-2bff5b05571349eca67722f080d308dd |
| Source note | uspto-grants-2008_11 |