Sulfuric Acid → Clopidogrel Bisulfate

Participants

Reaction Steps

Converting the (S) Clopidogrel camphor sulfonate salt (ISII) to (S) Clopidogrel free base of formula (IS) by the conventional technique. Dissolving the resolved (S) Clopidogrel base (IS) in glacial acetic acid at room temperature; followed by adding an antisolvent containing sulfuric acid to the solution at room temperature. Stirring the reaction mixture for 24 hours at room temperature, filtering and drying the crystals to obtain Form I of Clopidogrel Bisulfate.

Provenance & Evidence