HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,6-Dimethoxy-1-indanone → 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxyindan-1-one, (E)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,6-Dimethoxy-1-indanone | HCID 75018 | — |
| Reactant | 1-Benzylpiperidine-4-carbaldehyde | HCID 89584 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Product | 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxyindan-1-one, (E)- | HCID 53394849 | — |
Reaction Steps
According to the process disclosed in U.S. Pat. No. 4,895,841, 5,6-dimethoxy-1-indanone was condensed with 1-benzyl-4-formylpiperidine in the presence of lithium diisopropylamide to give 5,6-dimethoxy-2-[[1-benzyl-4-piperidinyl]methylene]-1-indanone, which was then reduced with platinum oxide catalyst to give donepezil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446203B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-8c3ead6fe54e4b57841ba89c8765abfe |
| Source note | uspto-grants-2008_11 |