Bromoacetonitrile → HCID 68956615, compound

Participants

Reaction Steps

5-(1-Benzofuran-2-yl)-8-hydroxy-quinoline was prepared as a solid (0.264 g, 99%) from 5-(1-benzofuran-2-yl)-8-methoxy-quinoline following the procedure described in the first part of Step 4 of Example 2. Mass spectrum (+ESI, [M+H]+) m/z 262. Reaction of 5-(1-benzofuran-2-yl)-8-hydroxy-quinoline with bromoacetonitrile according to the procedure described in Step 2 of Example 1 afforded the title compound as a solid (0.104 g, 34%). Mass spectrum (+ESI, [M+H]+) m/z 301. 1H NMR (500 MHz, DMSO-d6): δ 9.02 (d, 1H, J=1.4 Hz), 8.99 (d, 1H, J=9.3 Hz), 8.07 (d, 1H, J=8.3 Hz), 7.68-7.81 (m, 3H), 7.54 (d, 1H, J=8.3 Hz), 7.28-7.46 (m, 3H), and 5.51 ppm (s, 2H).

Provenance & Evidence