Bromoacetonitrile → HCID 68961432, compound

Participants

Reaction Steps

5-(3-Phenyl-1-benzofuran-2-yl)-8-hydroxy-quinoline was prepared as a solid (0.185 g, 99%) from 5-(3-phenyl-1-benzofuran-2-yl)-8-methoxy-quinoline according to the procedure described in the first part of Step 4 of Example 2; Mass spectrum (+ESI, [M+H]+) m/z 338. Reaction of 5-(3-phenyl-1-benzofuran-2-yl)-8-hydroxy-quinoline with bromoacetonitrile according to the procedure described in Step 2 of Example 1 afforded the title compound as a solid (0.148 g, 74%). Mass spectrum (+ESI, [M+H]+) m/z 377. 1H NMR (400 MHz, DMSO-d6): δ 8.90-8.96 (m, 1H), 8.19 (d, 1H, J=8.1 Hz), 7.71-7.81 (m, 3H), 7.39-7.65 (m,4H), 7.25-7.39 (m, 5H), and 5.48 ppm (s, 2H).

Provenance & Evidence