反应详情

A 1 l, four-necked flask equipped with a mechanical stirrer, thermometer pocket and condenser, was charged with 3-isobutyl glutaric acid (500 g) and acetic anhydride (326 g). The reaction mixture was refluxed at 135°-1450° C. for 2.5-3 hours, followed by distilling out the unreacted acetic anhydride at 147°-155° C., and then the distillation was continued under vacuum to ensure removal of traces of unreacted acetic anhydride. The residue was cooled to 25°-30° C. to obtain 445 g of 3-isobutylglutaric anhydride.

1. customA 1 l, four-necked flask equipped with a mechanical stirrer
2. temperatureThe reaction mixture was refluxed at 135°-1450° C. for 2.5-3 hours
3. distillationby distilling out the unreacted acetic anhydride at 147°-155° C.
4. distillationthe distillation
5. customremoval of traces of unreacted acetic anhydride
6. temperatureThe residue was cooled to 25°-30° C.