HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 3-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester | HCID 53834251 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol | HCID 21322562 | — |
Reaction Steps
A solution of 32 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester in 300 ml. of absolute THF is added dropwise, under nitrogen, to a suspension of 4.6 g. of LiAlH4 in 200 ml. of THF and the mixture is heated under reflux for one hour. After cooling, ethyl acetate, water and 32% sodium hydroxide solution are added and the mixture is worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol, m.p. 82°-84°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04151302 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-226f9c79dfce4dac9693709436aac917 |
| Source note | uspto-grants-1979_04 |