Pyridine → 1-Acetoxy-3-(2',4'-difluoro-4-biphenylyl)-3-butanol

HRID 26945Notes

Reaction equation

HRID 26945 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([OH:20])([CH3:19])[CH2:16][CH2:17][OH:18])=[CH:11][CH:10]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22].N1C=CC=CC=1.C(Cl)(Cl)Cl>O>[C:21]([O:18][CH2:17][CH2:16][C:15]([C:12]1[CH:13]=[CH:14][C:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])=[CH:10][CH:11]=1)([OH:20])[CH3:19])(=[O:23])[CH3:22]

Participants

6

Reactant 4

HCID 1049PyridineHCID 6212ChloroformHCID 7918Acetic AnhydrideHCID 213225623-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol

Product 1

HCID 213225611-Acetoxy-3-(2',4'-difluoro-4-biphenylyl)-3-butanol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 3 g. of 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol, 5 ml. of acetic anhydride and 8 ml. of pyridine is allowed to stand for 15 hours at 20°, poured into ice water and worked up with chloroform and water to give 1-acetoxy-3-(2',4'-difluoro-4-biphenylyl)butan-3-ol.

Workup

  1. additionA mixture of 3 g

Sources & evidence

ORD record
ord-5184800afad54fbdaffa6c54ef95e54a
Source dataset
uspto-grants-1979_04
Patent number
US04151302

Reaction notes

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