Formic Acid → 1-Formyloxy-3-(2',4'-difluoro-4-biphenylyl)butan-3-ol

HRID 26946Notes

Reaction equation

HRID 26946 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([OH:20])([CH3:19])[CH2:16][CH2:17][OH:18])=[CH:11][CH:10]=1.[CH:21](O)=[O:22]>>[CH:21]([O:18][CH2:17][CH2:16][C:15]([C:12]1[CH:13]=[CH:14][C:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])=[CH:10][CH:11]=1)([OH:20])[CH3:19])=[O:22]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 213225623-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol

Product 1

HCID 213225931-Formyloxy-3-(2',4'-difluoro-4-biphenylyl)butan-3-ol

Procedure

3 g. of 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol and 15 ml. of formic acid are warmed to 80° for 2 hours. The mixture is cooled and worked up in the customary manner to give 1-formyloxy-3-(2',4'-difluoro-4-biphenylyl)butan-3-ol.

Workup

  1. temperatureThe mixture is cooled

Sources & evidence

ORD record
ord-38be385089aa476a93c613708f1174ba
Source dataset
uspto-grants-1979_04
Patent number
US04151302

Reaction notes

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