反应详情

A mixture of 18.9 g (100 mmol) of 2-bromo-4-fluorotoluene, 17.8 g (100 mmol) of N-bromosuccinimide, 400 mg of benzoyl peroxide, and 200 ml of CCl4 were refluxed for 2 h. The reaction mixture was filtered through a glass frit (G2), and the precipitate was additionally washed with 3×50 ml of CCl4. The combined filtrate was evaporated to dryness. Fractional distillation of the residue (bp 92-96° C./4 mm Hg) gave the title product as colorless oil. Yield 20.4 g (76%).

1. temperaturewere refluxed for 2 h
2. filtrationThe reaction mixture was filtered through a glass frit (G2)
3. washthe precipitate was additionally washed with 3×50 ml of CCl4
4. customThe combined filtrate was evaporated to dryness
5. distillationFractional distillation of the residue (bp 92-96° C./4 mm Hg)