Triethylamine → 5-Bromo-N-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

Participants

Reaction Steps

To a suspension of 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (950 mg, 3.94 mmol) in DCM (20 mL) and DMF (0.1 mL) was added oxalyl chloride (600 mg, 4.72 mmol) slowly. The mixture was stirred at RT for 1 h. To this suspension was then added a solution of 2,3-difluorophenyl amine (610 mg, 4.72 mmol) and triethylamine (800 mg, 7.91 mmol) in DCM (5 mL). The reaction was kept at RT for another 2 h. The solvent was then evaporated, the residue was washed water, and dried for direct use. MS (ES+): m/e=352 (M+H); LC: 3.5 min.

Provenance & Evidence