Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitrogen | HCID 947 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-bromo-1H-indazole | HCID 761929 | — |
| Reactant | 1-vinyltriazole | HCID 11309474 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 69208499 | HCID 69208499 | — |
Reaction Steps
A mixture of 5-bromo-azaindole (1 g, 5.1 mmol), 1-vinyltriazole (600 mg, 6.3 mmol), and triethylamine (5 mL) was dissolved in DMF (25 mL). The solution was treated with N2 gas and PdCl2(dppf) (250 mg, 0.3 mmol) was added. The reaction was heated with stirring at 120° C. for 16 h and evaporated under vacuum. The residue DMF solution was poured into water, filtered, the solid was washed with ether. After drying on the pump for overnight, the crude solid was used for the next reaction directly (800 mg, 3.8 mmol). MS (ES+): m/e=212.1 (M+H); LC: 2.2 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07446199B2 |
|---|
| Source dataset | uspto-grants-2008_11 |
|---|
| ORD ID | ord-5d1f4dab7a954c0db72c0030efcaabdd |
|---|
| Source note | uspto-grants-2008_11 |
|---|
