Sodium Hydroxide → HCID 135424634, compound

Participants

Reaction Steps

N-(2,3-Difluoro-phenyl)-N′-amino-1H-pyrrolo[2,3-b]pyridine-3-carboxamidine (prepared by using procedures described in Method G) (20 mg, 0.07 mmol) was dissolved in 2N HCl (2 mL)). A solution of NaNO2 (6 mg) in water (1 mL) was added at 0° C. The mixture was stirred at 0° C. for 30 min and neutralized with 6N NaOH. The precipitate was collected by filtration and the crude product was purified by HPLC to afford a white solid (12 mg, 0.04 mmol).

Provenance & Evidence