反应详情

温度

70 °C

2-[1-(Toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl ]-cyclopropanecarboxylic acid ethyl ester, (153 mg, 0.4 mmol), was added to 2 mL ethanol and sodium ethoxide solution, (˜2.68M, 300 μL, 0.8 mmol), was added. The mixture was heated to 70° C. for 3 hours. The mixture was cooled to rt and several mL sat. ammonium chloride solution were added. The mixture was extracted with dichloromethane and the organic layers evaporated affording 85 mg essentially pure 2-(1H-Pyrrolo[2,3-b]pyridin-5-yl)-cyclopropanecarboxylic acid ethyl ester, which was used without further purification. MS ES+231.1.

1. additionwas added
2. temperatureThe mixture was cooled to rt
3. extractionThe mixture was extracted with dichloromethane
4. customthe organic layers evaporated