Phosphorus oxychloride → HCID 59832231, compound

Participants

Reaction Steps

To 4-[(2,3-Difluoro-phenyl)-acetyl]-1H-pyrrole-2-carboxylic acid (2,2-dimethoxy-ethyl)-methyl-amide (200 mg, 0.55 mmol) in dioxane (50 mL) was added POCl3 (50 μL, 0.55 mmol) at 0C. The reaction solution was heated to 60C and stirred for 14 hr. The reaction was quenched with water and extracted with ethyl acetate, dried (Na2SO4). Flash chromatography (methylene chloride/methanol) gave 67 mg (41% yield)of title compound.

Provenance & Evidence