HRID269528

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7918

Acetic anhydride

C4H6O3

结构：CCOC(=O)c1cc(N)cc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1

HCID58731004

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cc(NC(C)=O)cc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1

HCID58730998

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

Acetic anhydride (53 mg, 0.5 mmol) was added to a solution of 5″-amino-2-benzyloxy-5-chloro-[1,1′;2′,1″]terphenyl-3″-carboxylic acid ethyl ester (96 mg, 0.21 mmol) in pyridine (2 ml) and the mixture left at room temperature for 1 hour. The resulting solution was diluted with diethyl ether, washed with 1M hydrochloric acid and saturated sodium bicarbonate solution, dried (MgSO4) and evaporated to dryness to yield the title compound as a colourless gum. (102 mg, 97%).

WORKUP

后处理

washwashed with 1M hydrochloric acid and saturated sodium bicarbonate solution
dry with materialdried (MgSO4)
customevaporated to dryness

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-acef4e26b0c04df7b2a8deb3140a092e
来源数据集: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07446222B2
来源说明: uspto-grants-2008_11

反应 SMILES

[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH2:8]([O:10][C:11]([C:13]1[CH:14]=[C:15]([C:20]2[C:21]([C:26]3[CH:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:27]=3[O:33][CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:16]=[C:17]([NH2:19])[CH:18]=1)=[O:12])[CH3:9]>N1C=CC=CC=1.C(OCC)C>[CH2:8]([O:10][C:11]([C:13]1[CH:14]=[C:15]([C:20]2[C:21]([C:26]3[CH:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:27]=3[O:33][CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:16]=[C:17]([NH:19][C:1](=[O:3])[CH3:2])[CH:18]=1)=[O:12])[CH3:9]