Hydrochloric Acid → HCID 58731011, compound

Participants

Reaction Conditions

Reaction Steps

2-Benzyloxy-5-chloro-5″-dimethanesulfonylamino-[1,1′;2′,1″]terphenyl-3″-carboxylic acid ethyl ester was dissolved in ethanol (5 ml) and 1M sodium hydroxide (1 ml, 1 mmol) and left at room temperature for 5 hours then heated at 50° C. for 1 hour. The resulting solution was diluted with water, acidified with 1M hydrochloric acid and extracted with diethyl ether. The organic phase was dried (MgSO4), evaporated to dryness and triturated with diethyl ether/iso-hexane to yield the title compound as a white solid. (21 mg, 46%).

Provenance & Evidence