1,2-Dichloroethane → HCID 10007831, compound

Participants

Reaction Steps

A mixture of 2-benzyloxy-5-chloro-[1,1′;2′,1″]terphenyl-2″-carboxylic acid (100 mg, 0.24 mmol), benzenesulphonamide (46 mg, 0.29 mmol), EDC (56 mg, 0.29 mmol), and 4-dimethylaminopyridine (5 mg, 0.03 mmol) in 1:1 dichloromethane/tetrahydrofuran (4 ml) was stirred at room temperature for 16 hours. The mixture was diluted with ethyl acetate (10 ml) and washed with aq. sodium bicarbonate (5 ml), dilute hydrochloric acid (5 ml), water (5 ml), and brine (5 ml). The organic phase was dried and evaporated. Purification by prep. HPLC gave the title compound. (27 mg 20%).

Provenance & Evidence