1-(Bromomethyl)-2,4-difluorobenzene → HCID 58730999, compound

HRID 269572Notes

Reaction equation

HRID 269572 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:14]2[N:19]=[C:18]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:17]=[CH:16][CH:15]=2)[CH:7]=1.[F:34]C1C=C(F)C=CC=1CBr>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][CH2:26][C:27]2[CH:28]=[CH:29][C:30]([F:33])=[CH:31][C:32]=2[F:34])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:14]2[N:19]=[C:18]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:17]=[CH:16][CH:15]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 902971-(Bromomethyl)-2,4-difluorobenzeneHCID 58730992Ethyl 6-(5'-chloro-2'-{[(4-fluorophenyl)methyl]oxy}2-biphenylyl)-2-pyridinecarboxylate

Product 1

HCID 58730999HCID 58730999, compound

Procedure

Prepared in a similar manner to ethyl 6-(5′-chloro-2′-{[(4-fluorophenyl)methyl]oxy}-2-biphenylyl)-2-pyridinecarboxylate but using 2,4-difluorobenzyl bromide in place of 4-fluorobenzyl bromide. LC/MS t=3.82, [MH+] 480.3

Sources & evidence

ORD record
ord-d104e838a208424e85bedf38e3bfa64e
Source dataset
uspto-grants-2008_11
Patent number
US07446222B2

Reaction notes

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