1-[(4-Fluorophenyl)methoxy]-2-iodo-4-(trifluoromethyl)benzene → 2'-Bromo-2-{[(4-fluorophenyl)methyl]oxy}-5-(trifluoromethyl)biphenyl

HRID 269573Notes

Reaction equation

HRID 269573 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1C1C=C(Cl)C=CC=1OCC1C=CC=CC=1.[F:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][O:31][C:32]2[CH:37]=[CH:36][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:34][C:33]=2I)=[CH:26][CH:25]=1>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:33]1[CH:34]=[C:35]([C:38]([F:41])([F:40])[F:39])[CH:36]=[CH:37][C:32]=1[O:31][CH2:30][C:27]1[CH:28]=[CH:29][C:24]([F:23])=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 211129221-[(4-Fluorophenyl)methoxy]-2-iodo-4-(trifluoromethyl)benzeneHCID 693094132'-Bromo-5-chloro-2-[(phenylmethyl)oxy]biphenyl

Product 1

HCID 693109592'-Bromo-2-{[(4-fluorophenyl)methyl]oxy}-5-(trifluoromethyl)biphenyl

Procedure

Prepared as for 2′-bromo-5-chloro-2-[(phenylmethyl)oxy]biphenyl but using 1-{[(4-fluorophenyl)methyl]oxy}-2-iodo-4-(trifluoromethyl)benzene instead of 4-chloro-2-iodo-1-[(phenylmethyl)oxy]benzene.

Sources & evidence

ORD record
ord-6b9d57e7b3d3450f8289ecd2d05eb9ae
Source dataset
uspto-grants-2008_11
Patent number
US07446222B2

Reaction notes

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