関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (2-Bromophenyl)boronic acid | HCID 2773294 | — |
| 反応物 | Toluene ethanol | HCID 21863594 | — |
| 反応物 | Ethyl 5-(acetylamino)-2-bromobenzoate | HCID 69309519 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Ethyl 4-(acetylamino)-2'-bromo-2-biphenylcarboxylate | HCID 69312172 | 49% |
反応手順
A mixture of 2-bromophenylboronic acid (1.61 g, 8.0 mmol), ethyl 5-(acetylamino)-2-bromobenzoate (2.15 g, 7.5 mmol), potassium carbonate (5.52 g, 40 mmol) and tetrakis(triphenylphosphine)palladium(0) (869 mg, 0.75 mmol) in 1:1 toluene/ethanol (40 ml) was stirred and heated at 90° C. under nitrogen for 2 hours. After cooling the mixture was diluted with diethyl ether and water and the organic phase dried (MgSO4) and evaporated to dryness. The residue was chromatographed with ethyl acetate/iso-hexane (2:3) to yield 1.33 g of the title compound as a white foam.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07446222B2 |
|---|
| 出典データセット | uspto-grants-2008_11 |
|---|
| ORD ID | ord-1892fcaeedce4a5c819686acab73fe16 |
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| 出典メモ | uspto-grants-2008_11 |
|---|
