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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 269579Generated: October 25, 2026

2'-Benzyloxy-biphenyl-2-boronic acid → Ethyl 4-methyl-2''-[(phenylmethyl)oxy]-1,1':2',1''-terphenyl-2-carboxylate

https://huagongshe.com/reaction/269579

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2'-Benzyloxy-biphenyl-2-boronic acidHCID 58730990—
ReactantEthyl 4-(acetylamino)-2''-[(phenylmethyl)oxy]-5''-(trifluoromethyl)-1,1':2',1''-terphenyl-2-carboxylateHCID 58731007—
ReactantEthyl 2'-bromo-4-methyl-2-biphenylcarboxylateHCID 69309503—
ProductEthyl 4-methyl-2''-[(phenylmethyl)oxy]-1,1':2',1''-terphenyl-2-carboxylateHCID 58730980—

Reaction Steps

Prepared in a similar way to ethyl 4-(acetylamino)-2″-[(phenylmethyl)oxy]-5″-(trifluoromethyl)-1,1′:2′,1″-terphenyl-2-carboxylate but using {2′-[(phenylmethyl)oxy]-2-biphenylyl}boronic acid instead of [2-[(phenylmethyl)oxy]-5-(trifluoromethyl)phenyl]boronic acid and ethyl 2′-bromo-4-methyl-2-biphenylcarboxylate instead of ethyl 4-(acetylamino)-2′-bromo-2-biphenylcarboxylate. LC/MS t=4.11, [MH+] 423.1

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07446222B2
Source datasetuspto-grants-2008_11
ORD IDord-129eee260339493b8790589d99367e09
Source noteuspto-grants-2008_11