反应详情

温度

0 °C

100 ml of a 1M diisobutylaluminum hydride solution in dichloromethane are added to a solution, cooled to 0° C., of 33.98 g (100.5 mmol) of 2-benzyloxy-5-iodobenzaldehyde (Example 2A) in 200 ml of dichloromethane. After stirring at 0° C. for 2 h, a saturated potassium sodium tartrate solution is added while cooling (highly exothermic reaction), and the reaction mixture is stirred for a further 2 h. After the separation of the phases, the organic phase is washed twice with water and once with a saturated aqueous sodium chloride solution and dried over sodium sulfate. The solvent is evaporated in vacuo. 31.8 g (93% of theory) of product are obtained.

1. temperaturewhile cooling (
2. customhighly exothermic reaction), and the reaction mixture
3. stirringis stirred for a further 2 h
4. customAfter the separation of the phases
5. washthe organic phase is washed twice with water and once with a saturated aqueous sodium chloride solution
6. dry with materialdried over sodium sulfate
7. customThe solvent is evaporated in vacuo
8. custom31.8 g (93% of theory) of product are obtained