反应详情

温度

100 °C

3.3 ml (35 mmol) of phosphorus tribromide are added dropwise to a solution of 35 g (103 mmol) of (2-benzyloxy-5-iodophenyl)methanol (Example 3A) in 350 ml of toluene at 40° C. The temperature of the reaction mixture is raised to 100° C. over the course of 15 min and the reaction mixture is stirred at this temperature for a further 10 min. After cooling, the two phases are separated. The organic phase is washed twice with distilled water and once with a saturated aqueous sodium chloride solution. The organic phase is dried over sodium sulfate and evaporated. The yield amounts to 41 g (99% of theory).

1. temperatureAfter cooling
2. customthe two phases are separated
3. washThe organic phase is washed twice with distilled water and once with a saturated aqueous sodium chloride solution
4. dry with materialThe organic phase is dried over sodium sulfate
5. customevaporated