HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2(S)-Amino-3-(2-benzyloxy-5-iodophenyl)propionic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-(benzyloxy)-N-(tert-butoxycarbonyl)-5-iodo-L-phenylalanine | HCID 58754147 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2(S)-Amino-3-(2-benzyloxy-5-iodophenyl)propionic acid hydrochloride | HCID 57463609 | — |
Reaction Steps
12 g (24.13 mmol) of 3-(2-benzyloxy-5-iodophenyl)-2(S)-tert-butoxycarbonylaminopropionic acid (Example (−)-6A) are added under argon into 60 ml of a 4M solution of hydrogen chloride in dioxane and stirred at RT for 2 h. The reaction solution is concentrated and dried under high vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446102B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-f2bad4cca80741709dac5cd6b713c539 |
| Source note | uspto-grants-2008_11 |