反应详情

A stirred solution of 10 g of N-[[2-[3-(dimethylamino)propoxy]phenyl]methyl]benzeneethanamine in 50 ml of chloroform is treated dropwise at 10° to 15° C. with 2.7 ml of methanesulfonyl chloride dissolved in 50 ml of chloroform, stirred for 1 hour at room temperature (some solid separates), refluxed for 1 hour (solution obtained), and maintained at room temperature for about 16 hours.

1. temperaturerefluxed for 1 hour
2. custom(solution obtained)
3. temperaturemaintained at room temperature for about 16 hours