Methanesulfonyl chloride → HCID 131711314, compound

HRID 26960Notes

Reaction equation

HRID 26960 reaction equation
[CH3:1][N:2]([CH3:23])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][NH:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[CH3:24][S:25]([Cl:28])(=[O:27])=[O:26]>C(Cl)(Cl)Cl>[ClH:28].[CH3:23][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][N:14]([CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[S:25]([CH3:24])(=[O:27])=[O:26]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 21322747N-[[2-[3-(Dimethylamino)propoxy]phenyl]methyl]benzeneethanamine

Product 1

HCID 131711314HCID 131711314, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A stirred solution of 10 g of N-[[2-[3-(dimethylamino)propoxy]phenyl]methyl]benzeneethanamine in 50 ml of chloroform is treated dropwise at 10° to 15° C. with 2.7 ml of methanesulfonyl chloride dissolved in 50 ml of chloroform, stirred for 1 hour at room temperature (some solid separates), refluxed for 1 hour (solution obtained), and maintained at room temperature for about 16 hours.

Workup

  1. temperaturerefluxed for 1 hour
  2. custom(solution obtained)
  3. temperaturemaintained at room temperature for about 16 hours

Sources & evidence

ORD record
ord-692080a4fcb94780bf3e33651c0b2f0a
Source dataset
uspto-grants-1979_04
Patent number
US04151354

Reaction notes

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