HRID26961

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C)CCCOc1ccccc1CN(CCc1ccc([N+](=O)[O-])cc1)C(=O)C=Cc1ccccc1.O=C(O)C(=O)O

HCID131710974

未命名化合物

HCID178418361

未命名化合物

2 次

PRODUCTS

生成物

结构：CN(C)CCCOc1ccccc1CN(CCc1ccc(N)cc1)C(=O)C=Cc1ccccc1.O=C(O)C(=O)O

HCID131710973

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A suspension of 10 parts of N-[[2-[3-(dimethylamino)propoxy]phenyl]methyl]-N-[2-(4-nitrophenyl)ethyl]-3-phenyl-2-propenamide, oxalate salt (1:1) in 100 ml of ethanol is treated with 1 part of 5% palladium on carbon and placed under 3 atmospheres of gaseous hydrogen. The mixture is shaken until one equivalent of hydrogen is consumed, filtered and the solvent evaporated under reduced pressure to give the title compound.

WORKUP

后处理

customis consumed
filtrationfiltered
customthe solvent evaporated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f9bd4d756401471aa00f69e7728aa7f0
来源数据集: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04151354
来源说明: uspto-grants-1979_04

反应 SMILES

[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH3:7][N:8]([CH3:42])[CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH2:19][N:20]([CH2:31][CH2:32][C:33]1[CH:38]=[CH:37][C:36]([N+:39]([O-])=O)=[CH:35][CH:34]=1)[C:21](=[O:30])[CH:22]=[CH:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[H][H]>C(O)C.[Pd]>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[NH2:39][C:36]1[CH:37]=[CH:38][C:33]([CH2:32][CH2:31][N:20]([CH2:19][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[O:12][CH2:11][CH2:10][CH2:9][N:8]([CH3:42])[CH3:7])[C:21](=[O:30])[CH:22]=[CH:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:34][CH:35]=1