HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl{(1S)-4-[(tert-butoxycarbonyl)amino]-1-[({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)carbonyl]butyl}carbamate → N5-(tert-Butoxycarbonyl)-N-{3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}-L-ornithinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl{(1S)-4-[(tert-butoxycarbonyl)amino]-1-[({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)carbonyl]butyl}carbamate | HCID 131727147 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N5-(tert-Butoxycarbonyl)-N-{3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}-L-ornithinamide | HCID 86619422 | — |
Reaction Steps
Preparation takes place in analogy to Example 81A from 412 mg (0.76 mmol) of benzyl{(1S)-4-[(tert-butoxycarbonyl)amino]-1-[({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)carbonyl]butyl}carbamate (Example 80A) in 50 ml of ethanol with the addition of 41 mg of palladium on activated carbon (10%). The product is reacted without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446102B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-4e0ee4f9bc8b49ac8eba7be265525cb3 |
| Source note | uspto-grants-2008_11 |