tert-butyl-{(4S)-5-azido-4-[(tert-butoxycarbonyl)amino]pentyl}carbamate → tert-Butyl {(4S)-5-amino-4-[(tert-butoxycarbonyl)amino]pentyl}carbamate

Participants

Reaction Steps

A solution of 188 mg (0.55 mmol) of tert-butyl{(4S)-5-azido-4-[(tert-butoxycarbonyl)amino]pentyl}carbamate (Example 85A) in ethanol is hydrogenated after the addition of 20 mg of palladium on activated carbon (10%) at RT under atmospheric pressure for 12 h. The mixture is filtered through kieselguhr, and the residue is washed with ethanol. The filtrate is evaporated to dryness in vacuo. The product is reacted without further purification.

Provenance & Evidence