HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (2S)-2,4-Bis[(tert-butoxycarbonyl)amino]butyl methanesulphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 57440192 | HCID 57440192 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2S)-2,4-Bis[(tert-butoxycarbonyl)amino]butyl methanesulphonate | HCID 86601681 | — |
Reaction Steps
Preparation takes place in analogy to Example 84A from 250 mg (0.81 mmol) of tert-butyl{(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutyl}carbamate (Example 89A) in 20 ml of dichloromethane with 110 mg (0.97 mmol) of methanesulfonyl chloride and 0.23 ml (1.6 mmol) of triethylamine. The product is reacted without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446102B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-66dc4b91028b4aafb09346fd1ff872a6 |
| Source note | uspto-grants-2008_11 |