1,2-Dichloroethane → HCID 131727149, compound

Participants

Reaction Conditions

Reaction Steps

85 mg (0.17 mmol) of 5-benzyloxycarbonylamino-2 (S)-tert-butoxycarbonylamino-4 (R)-(tert-butyldimethylsilanyloxy)pentanoic acid (Example 14A), 67.1 mg (0.29 mmol) of benzyl-(2-aminoethyl)carbamate hydrochloride and 0.05 ml (0.29 mmol) of diisopropylethylamine are dissolved in 3 ml of DMF and cooled to 0° C. 55.8 mg (0.29 mmol) of EDC and 7.6 mg (0.06 mmol) of HOBT are added, and the mixture is allowed to warm to room temperature and is stirred overnight. The mixture is then concentrated in vacuo and purified by chromatography on silica gel (dichloromethane/methanol 20:1)

Provenance & Evidence