Benzyl[(1S)-2-({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)-1-(hydroxymethyl)-2-oxoethyl]carbamate → N-{3-[(tert-Butoxycarbonyl)amino]-2-hydroxypropyl}-L-serinamide

Participants

Reaction Steps

131 mg (0.318 mmol) of benzyl[(1S)-2-({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)-1-(hydroxymethyl)-2-oxoethyl]carbamate (Example 100A) are dissolved in 20 ml of ethanol. 20 mg of palladium on activated carbon (10%) are added thereto, and the mixture is hydrogenated under atmospheric pressure for 15 h. The reaction mixture is filtered through prewashed kieselguhr, and the filtrate is concentrated in vacuo on a rotary evaporator. The crude product is reacted without further purification.

Provenance & Evidence