化工社化工社 化学情報印刷レポート · 研究参考用
1,2-Dichloroethane → Benzyl {(1S)-1-[({(2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)carbonyl]-4-[(tert-butoxycarbonyl)amino]butyl}carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dichloroethane | HCID 11 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | Z-Ndelta-Boc-L-ornithine | HCID 7350734 | — |
| 反応物 | HCID 57440197 | HCID 57440197 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Benzyl {(1S)-1-[({(2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)carbonyl]-4-[(tert-butoxycarbonyl)amino]butyl}carbamate | HCID 86624497 | — |
反応手順
Preparation takes place in analogy to Example 79A from 120 mg (0.33 mmol) of N5-(tert-butoxycarbonyl)-N2-[(benzyloxy)carbonyl]-L-ornithine and 136 mg (0.43 mmol) of tert-butyl{(4S)-5-amino-4-[(tert-butoxycarbonyl)amino]pentyl}carbamate (Example 86A) in 6 ml of dimethylformamide with the addition of 82 mg (0.43 mmol) of EDC and 13 mg (0.1 mmol) of HOBt. The product is purified by preparative RP-HPLC (mobile phase water/acetonitrile gradient: 90:10→5:95).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07446102B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-6a5d5f563a0641039e4b732bbdf3c5f7 |
| 出典メモ | uspto-grants-2008_11 |