反应详情

A solution of 128 mg (0.77 mmol) of benzyl[(1S)-1-[(benzyloxy)methyl]-2-({(2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)-2-oxoethyl]carbamate (Example 127A) in 50 ml of ethanol is hydrogenated after the addition of 13 mg of palladium on activated carbon (10%) at RT under atmospheric pressure for 48 h. The mixture is filtered through kieselguhr and the residue is washed with ethanol. The filtrate is evaporated to dryness in vacuo. The product is purified by preparative RP-HPLC (mobile phase water/acetonitrile gradient: 90:10→5:95).

1. filtrationThe mixture is filtered through kieselguhr
2. washthe residue is washed with ethanol
3. customThe filtrate is evaporated to dryness in vacuo
4. customThe product is purified by preparative RP-HPLC (mobile phase water/acetonitrile gradient: 90:10→5:95)