HCID 131727158, compound → HCID 88986933, compound

Participants

Reaction Steps

25 mg (0.048 mmol) of benzyl[(3S)-3-[(tert-butoxycarbonyl)amino]-4-({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)-4-oxobutyl]carbamate (Example 154A) are dissolved in 10 ml of ethanol. 10 mg of palladium on activated carbon (10%) are added thereto, and the mixture is then hydrogenated under atmospheric pressure for 15 h. The reaction mixture is filtered through prewashed kieselguhr, and the filtrate is concentrated on a rotary evaporator in vacuo. The crude product is reacted without further purification.

Provenance & Evidence