HCID 131727159, compound → HCID 88986877, compound

Participants

Reaction Steps

116 mg (0.186 mmol) of di-tert-butyl[2-({(2S)-4-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]butanoyl}amino)propane-1,3-diyl]biscarbamate (Example 156A) are dissolved in 20 ml of ethanol. 30 mg of palladium on activated carbon (10%) are added thereto, and the mixture is then hydrogenated under atmospheric pressure for 15 h. The reaction mixture is filtered through prewashed kieselguhr and the filtrate is concentrated on a rotary evaporator in vacuo. The crude product is reacted without further purification.

Provenance & Evidence