HCID 131727170, compound → HCID 88986893, compound

HRID 269676Notes

Reaction equation

HRID 269676 reaction equation
C([N:5]([CH:9]([CH2:23][C:24]([NH:26][CH2:27][C@@H:28]([NH:40][C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:29][CH2:30][CH2:31][NH:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])=[O:25])[CH2:10][CH2:11][NH:12][C:13](=[O:22])[O:14]CC1C=CC=CC=1)C(=O)[O-])(C)(C)C>[Pd].C(O)C>[C:36]([O:14][C:13](=[O:22])[NH:12][CH2:11][CH2:10][CH:9]([NH2:5])[CH2:23][C:24]([NH:26][CH2:27][C@@H:28]([NH:40][C:41]([O:43][C:44]([CH3:46])([CH3:47])[CH3:45])=[O:42])[CH2:29][CH2:30][CH2:31][NH:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])=[O:25])([CH3:39])([CH3:38])[CH3:37]

Participants

4

Reactant 1

HCID 131727170HCID 131727170, compound

Product 1

HCID 88986893HCID 88986893, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

35 mg of palladium on activated carbon (10%) are added to a mixture of 0.232 g (0.35 mmol) of the compound from Example 244A in 10 ml of ethanol, and the mixture is then hydrogenated under atmospheric pressure for 12 h. The reaction mixture is filtered through kieselguhr, and the filtrate is concentrated in vacuo and dried under high vacuum. The crude product is reacted without further purification.

Workup

  1. filtrationThe reaction mixture is filtered through kieselguhr
  2. concentrationthe filtrate is concentrated in vacuo
  3. customdried under high vacuum
  4. customThe crude product is reacted without further purification

Sources & evidence

ORD record
ord-507c04d4dba045439cbd8dfaac75203d
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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