HCID 69493637, compound → HCID 86619445, compound

HRID 269684Notes

Reaction equation

HRID 269684 reaction equation
C(OC(=O)[NH:10][CH2:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:14])C1C=CC=CC=1>[Pd].C(O)C>[C:22]([O:21][C:19]([NH:18][CH2:17][CH2:16][NH:15][C:13](=[O:14])[CH2:12][CH2:11][NH2:10])=[O:20])([CH3:25])([CH3:23])[CH3:24]

Participants

4

Reactant 1

HCID 69493637HCID 69493637, compound

Product 1

HCID 86619445HCID 86619445, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

80 mg of palladium on activated carbon (10%) are added to a mixture of 0.30 g (0.82 mmol) of the compound from Example 254A in 10 ml of ethanol, and the mixture is then hydrogenated under atmospheric pressure for 12 h. The reaction mixture is filtered through kieselguhr, and the filtrate is concentrated in vacuo and dried under high vacuum. The crude product is reacted without further purification.

Workup

  1. filtrationThe reaction mixture is filtered through kieselguhr
  2. concentrationthe filtrate is concentrated in vacuo
  3. customdried under high vacuum
  4. customThe crude product is reacted without further purification

Sources & evidence

ORD record
ord-4cdc0a2603814763878ae61d8cd8cc04
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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